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C-DMT, also known as N,N-dimethyl-2-(3H-inden-1-yl)ethylamine, is a serotonin receptor agonist and a 3-indenyl ethyl amine derivative. [ 1 ] [ 2 ] [ 3 ] It is an analogue and bioisostere of the tryptamine psychedelic N , N -dimethyltryptamine (DMT) in which the indole ring has been replaced with an indene ring.
6-MeO-DMT, or 6-methoxy-N,N-dimethyltryptamine, also known as 6-OMe-DMT, is a serotonergic drug of the tryptamine family. [ 1 ] [ 2 ] It is the 6- methoxy derivative of the serotonergic psychedelic N , N -dimethyltryptamine (DMT) and is a positional isomer of the serotonergic psychedelic 5-MeO-DMT .
N,N-Dimethyltryptamine (DMT or N,N-DMT) is a substituted tryptamine that occurs in many plants and animals, including humans, and which is both a derivative and a structural analog of tryptamine. [1] [2] [3] DMT is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen. [9]
As with DMT, CYB004 is a potent agonist of the serotonin 5-HT 2A receptor and produces psychedelic-like effects in animals. [ 1 ] [ 5 ] [ 3 ] However, CYB004, due to its deuteration, is more resistant to metabolism than DMT and shows a longer elimination half-life (by 2.5- to 2.9-fold) and slower clearance (by 38 to 55%) in animals. [ 3 ]
The term psychoplastogen comes from the Greek roots psych - (mind), - plast (molded), and - gen (producing) and covers a variety of chemotypes and receptor targets. It was coined by David E. Olson in collaboration with Valentina Popescu, both at the University of California, Davis.
The lack of tolerance development with 5-MeO-DMT may be due to biased agonism of the serotonin 5-HT 2A receptor. [5] More specifically, 5-MeO-DMT activates the G q signaling pathway of the serotonin 5-HT 2A receptor with much less potency in recruiting β-arrestin2. [5] [22] Activation of β-arrestin2 is linked to receptor downregulation and ...
Psychedelic therapy (or psychedelic-assisted therapy) is the proposed use of psychedelic drugs to treat mental disorders. [60] As of 2021, psychedelic drugs are controlled substances in most countries and psychedelic therapy is not legally available outside clinical trials, with some exceptions. [34] [61]
NBoc-DMT, or NB-DMT, also known as N1-tert-butoxycarbonyl-N,N-dimethyltryptamine, is a serotonergic psychedelic of the tryptamine family. [ 1 ] [ 2 ] It is a novel designer and recreational drug and is a synthetic modification of dimethyltryptamine (DMT) with an N′ - tert -butyloxycarbonyl (NBoc) group .