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Calcium channels mediate the influx of calcium ions into the cell upon membrane depolarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits.
The concentration of calcium (Ca 2+ ions) is normally several thousand times higher outside the cell than inside. Activation of particular VGCCs allows a Ca 2+ influx into the cell, which, depending on the cell type, results in activation of calcium-sensitive potassium channels , muscular contraction , [ 4 ] excitation of neurons, up-regulation ...
Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene. [5] This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and ...
It is sometimes synonymous with voltage-gated calcium channel, [1] which are a type of calcium channel regulated by changes in membrane potential. Some calcium channels are regulated by the binding of a ligand. [2] [3] Other calcium channels can also be regulated by both voltage and ligands to provide precise control over ion flow. Some cation ...
Studies have shown that the intrathecal injection of the calcium channel inhibitor ziconotide, to block the N-type calcium channels, have produced alleviation of intractable pain. [12] Blockade of the N-type calcium channel is a potential therapeutic strategy for the treatment of alcoholism. Because prolonged alcohol exposure over time has been ...
Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar ...
Ca v 2.1 plays an important role in controlling the release of neurotransmitters between neurons. [5] It is composed of multiple subunits, including alpha-1, beta, alpha-2/delta, and gamma subunits. [6] The alpha-1 subunit is the pore-forming subunit, meaning that the calcium ions flow through it. [6]
An L-type calcium channel with its subunits labeled along with some drugs known to inhibit the channel. The L-type calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium channel. [2] "L" stands for long-lasting referring to the length of activation.