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The main effect on cardiovascular morbidity is in patients with the metabolic syndrome, the features of which are attenuated by bezafibrate. [3] Studies show that in patients with impaired glucose tolerance, bezafibrate may delay progress to diabetes, [4] and in those with insulin resistance it slowed progress in the HOMA severity marker. [5]
PPARα (alpha) is the main target of fibrate drugs, a class of amphipathic carboxylic acids (clofibrate, gemfibrozil, ciprofibrate, bezafibrate, and fenofibrate). They were originally indicated for dyslipidemia of cholesterol and more recently for disorders characterized by high triglycerides.
Gestational diabetes is a condition in which a woman without diabetes develops high blood sugar levels during pregnancy. [ 4 ] Type 2 diabetes mellitus and prediabetes are associated with changes in levels of metabolic markers, these markers could serve as potential prognostic or therapeutic targets for patients with prediabetes or Type 2 ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 29 January 2025. Group of endocrine diseases characterized by high blood sugar levels This article is about the common insulin disorder. For the urine hyper-production disorder, see Diabetes insipidus. For other uses, see Diabetes (disambiguation). Medical condition Diabetes Universal blue circle symbol ...
Although less effective in lowering LDL levels, the ability of fibrates to increase HDL and lower triglyceride levels seems to reduce insulin resistance when the dyslipidemia is associated with other features of the metabolic syndrome (hypertension and diabetes mellitus type 2). [6] They are therefore used in many hyperlipidemias. Due to a rare ...
A linear biochemical pathway is a chain of enzyme-catalyzed reaction steps where the product of one reaction becomes the substrate for the next reaction.The molecules progress through the pathway sequentially from the starting substrate to the final product.
Bile acid sequestrants are polymeric compounds that serve as ion-exchange resins.Bile acid sequestrants exchange anions such as chloride ions for bile acids. By doing so, they bind bile acids and sequester them from the enterohepatic circulation.
Biochemical Pharmacology is a peer-reviewed medical journal published by Elsevier. It covers research on the pharmacodynamics and pharmacokinetics of drugs and non-therapeutic xenobiotics . The editor-in-chief is Jacques Piette, University of Liege .