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Buspirone augmentation was not found to increase the discontinuation success rate. [86] Caffeine may worsen withdrawal symptoms because of its stimulatory properties. [25] At least one animal study has shown some modulation of the benzodiazepine site by caffeine, which produces a lowering of seizure threshold. [87]
Buspirone, sold under the brand name Buspar among others, is an anxiolytic, a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder (GAD). [ 10 ] [ 11 ] It is a serotonin 5-HT 1A receptor partial agonist , increasing action at serotonin receptors in the brain. [ 3 ]
Syncope; Hypotension; Hypertension; Redness and itching of the eyes; Altered taste; Conjunctivitis; Flatulence; Anorexia; Increased appetite; Salivation; Rectal bleeding
Buspirone. Buspirone is an azapirone medication that’s used to treat certain anxiety disorders, though it does have some limitations. Like SSRIs, buspirone may take several weeks of treatment to ...
Deprescribing can improve adherence, cost, and health outcomes but may have adverse drug withdrawal effects. More specifically, deprescribing is the planned and supervised process of intentionally stopping a medication or reducing its dose to improve the person's health or reduce the risk of adverse side effects. Deprescribing is usually done ...
Buspirone is sometimes used off-label to reduce sexual dysfunction associated with the use of SSRIs. [ 54 ] [ 55 ] [ 56 ] A number of non-SSRI drugs are not associated with sexual side effects (such as bupropion , mirtazapine , tianeptine , agomelatine , tranylcypromine , and moclobemide [ 57 ] [ 58 ] [ 59 ] ).
Approximately 20–50% of people who suddenly stop an antidepressant develop an antidepressant discontinuation syndrome. [187] [13] [188] The condition is generally not serious. [187] Though about half of people with symptoms describe them as severe. [188] Some restart antidepressants due to the severity of the symptoms. [188]
Management is based primarily on stopping the usage of the precipitating drugs, the administration of serotonin antagonists such as cyproheptadine (with a regimen of 12 mg for the initial dose followed by 2 mg every 2 hours until clinical, while some claim that a higher initial dose up to 32 mg has more benefit [65]), [66] and supportive care ...