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House then visits Stacy, who reveals she's leaving now that Mark is getting better. Margo is discharged, but while leaving she has a stroke and collapses. The team begins to work on diagnosing Margo's new symptoms. House suspects the fertility treatments caused endometrial cancer. On the roof, Stacy meets with House.
House decides that Maria must be poisoning Bob, as any heavy metal that could enter his system by other means has been tested for. House searches Maria, but finds nothing. Still certain that Maria is the culprit, House retrieves a vial of liquid to test his theory, instructing Cameron to prevent Maria from using the bathroom until he returns.
House goes to see the patient before he is transferred. He finds his wife and tells her that her husband has a lymph node tumor and requires full body radiation therapy and plasmapheresis . During the last day of the hearing, Dr. Colfield calls House brilliant but a fiasco; however, the patient's wife speaks up on House's behalf, saying House ...
House says that's different - the patient has an arsenal, and House denies owning a gun. Wilson tells him he does and, as a felon, if he's caught with it he could go back to jail. House says he doesn't need a gun, the only thing worth stealing would require a crane to remove it.
While House delivers his diagnosis, Elizabeth overhears the news and leaves. House recommends they test the blood again visually to confirm the diagnosis – cerebral malaria . Foreman is shocked and upset because if anyone had actually looked at the blood and not just run it through a computer, Fletcher would've been diagnosed instantly.
After losing a bet on a boxing match to Wilson, House sets out to prove the fighter he bet on (Kevin Phillips) lost due to an underlying medical condition. House also begins injecting himself with an experimental drug reported to regrow muscle in rats. The team treats a scientist, Dr. Lee for seizures and symptoms of radiation poisoning
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House finds it surprising that Jeff admitted he is taking illegal enhancement drugs. He agreed to blood doping, which is common among cyclists, to better one's athletic performance. Because red blood cells carry oxygen between the lungs and the muscles, a higher number of red blood cells can increase an athlete's endurance.