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  2. CD4 - Wikipedia

    en.wikipedia.org/wiki/CD4

    Image of CD4 co-receptor binding to MHC (Major Histocompatibility Complex) non-polymorphic region. In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells.

  3. T helper cell - Wikipedia

    en.wikipedia.org/wiki/T_helper_cell

    The binding of the antigen-MHC to the TCR complex and CD4 may also help the APC and the T h cell adhere during T h cell activation, but the integrin protein LFA-1 on the T cell and ICAM on the APC are the primary molecules of adhesion in this cell interaction.

  4. Major histocompatibility complex - Wikipedia

    en.wikipedia.org/wiki/Major_histocompatibility...

    On the cell's surface, the epitope can be recognized by immunologic structures like T-cell receptors (TCRs). The molecular region which binds to the epitope is the paratope. On surfaces of helper T cells are CD4 receptors, as well as TCRs.

  5. Co-receptor - Wikipedia

    en.wikipedia.org/wiki/Co-receptor

    The CD family of co-receptors are a well-studied group of extracellular receptors found in immunological cells. [4] The CD receptor family typically act as co-receptors, illustrated by the classic example of CD4 acting as a co-receptor to the T cell receptor (TCR) to bind major histocompatibility complex II (MHC-II). [5]

  6. CD4 immunoadhesin - Wikipedia

    en.wikipedia.org/wiki/CD4_immunoadhesin

    CD4-Ig works by mimicking the binding of CD4 to HIV, thereby preventing the virus from infecting T-helper cells. HIV infects T-helper cells by binding to the CD4 receptor and the co-receptor CCR5 or CXCR4. CD4-Ig binds to the viral envelope glycoprotein gp120, which is responsible for HIV binding to CD4. By binding to gp120, CD4-Ig prevents the ...

  7. T cell - Wikipedia

    en.wikipedia.org/wiki/T_cell

    A thymocyte's fate is determined during positive selection. Double-positive cells (CD4 + /CD8 +) that interact well with MHC class II molecules will eventually become CD4 + "helper" cells, whereas thymocytes that interact well with MHC class I molecules mature into CD8 + "killer" cells. A thymocyte becomes a CD4 + cell by down-regulating ...

  8. Cluster of differentiation - Wikipedia

    en.wikipedia.org/wiki/Cluster_of_differentiation

    Human immunodeficiency virus binds CD4 and a chemokine receptor on the surface of a T helper cell to gain entry. The number of CD4 and CD8 T cells in blood is often used to monitor the progression of HIV infection .

  9. Antigen presentation - Wikipedia

    en.wikipedia.org/wiki/Antigen_presentation

    Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells.. Antigen presentation is a vital immune process that is essential for T cell immune response triggering.