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  2. General paresis of the insane - Wikipedia

    en.wikipedia.org/wiki/General_paresis_of_the_insane

    General paresis, also known as general paralysis of the insane (GPI), paralytic dementia, or syphilitic paresis is a severe neuropsychiatric disorder, classified as an organic mental disorder, and is caused by late-stage syphilis and the chronic meningoencephalitis and cerebral atrophy that are associated with this late stage of the disease when left untreated.

  3. Neurosyphilis - Wikipedia

    en.wikipedia.org/wiki/Neurosyphilis

    Neurosyphilis is the infection of the central nervous system by Treponema pallidum, the bacterium that causes the sexually transmitted infection syphilis.In the era of modern antibiotics, the majority of neurosyphilis cases have been reported in HIV-infected patients.

  4. Syphilis - Wikipedia

    en.wikipedia.org/wiki/Syphilis

    Syphilis (/ ˈ s ɪ f ə l ɪ s /) is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. [1] The signs and symptoms depend on the stage it presents: primary, secondary, latent or tertiary.

  5. Tabes dorsalis - Wikipedia

    en.wikipedia.org/wiki/Tabes_dorsalis

    Tabes dorsalis is caused by demyelination by advanced syphilis infection (tertiary syphilis) when the primary infection by the causative spirochete bacterium, Treponema pallidum, is left untreated for an extended period of time (past the point of blood infection by the organism). [3]

  6. Meningeal syphilis - Wikipedia

    en.wikipedia.org/wiki/Meningeal_syphilis

    Meningeal syphilis (as known as syphilitic aseptic meningitis or meningeal neurosyphilis) is a chronic form of syphilis infection that affects the central nervous system. Treponema pallidum , a spirochate bacterium, is the main cause of syphilis, which spreads drastically throughout the body and can infect all its systems if not treated ...

  7. History of syphilis - Wikipedia

    en.wikipedia.org/wiki/History_of_syphilis

    The history of syphilis has been well studied, but the exact origin of the disease was the source of debate until archaeological and genetic evidence showed conclusively it originated in the Americas.

  8. Treponema - Wikipedia

    en.wikipedia.org/wiki/Treponema

    The major treponeme species of human pathogens is Treponema pallidum, whose subspecies are responsible for diseases such as syphilis, bejel, and yaws. Treponema carateum is the cause of pinta. [2] Treponema paraluiscuniculi is associated with syphilis in rabbits. [3]

  9. Gumma (pathology) - Wikipedia

    en.wikipedia.org/wiki/Gumma_(pathology)

    In syphilis, the gumma is caused by a reaction to spirochaete bacteria in the tissue. It appears to be the human body's way to slow down the action of this bacteria; it is a unique immune response that develops in humans after the immune system fails to kill off syphilis. [citation needed]