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Frey's syndrome is due to parasympathetic nerve fiber regrowth innervating sweat glands and blood vessels in the facial skin. Produces gustatory sweating, warmth and flushing in the preauricular and temporal area.
Key Clinical Message. Frey's syndrome is the most common adverse event after parotidectomy, and usually, it appears after 6 months. In our case, symptoms appear 20 years from surgery, an uncommon condition. Intralesional botulinum toxin gives excellent results in therapy, regardless of the time elapsed between surgery and the first treatment.
It’s often a side effect of parotid gland surgery and happens due to nerve damage and abnormal nerve regrowth. Botox® injections can help manage the sweating. Contents Overview Symptoms and Causes Diagnosis and Tests Management and Treatment Prevention Outlook / Prognosis Living With.
This article outlines a comprehensive diagnostic algorithm for Frey's syndrome, which includes the utilization of the Minor-Starch-Iodine Test. This test is a key component in diagnosing the syndrome and is discussed in detail, providing insights into its procedure and interpretation.
Our results suggested that the effective rate of BTXA for treatment of FS is 98.5% (95% CI = 0.971–0.994) and the incidence of complication is 3.6% (95% CI = 0.017–0.061). In conclusion, our study supports that BTXA produces meaningful benefits on the treatment of patients with FS.
Although botulinum toxin type A has become first-line therapy for Frey’s syndrome, some patients become resistant. In this study, we investigated whether another serotype, botulinum toxin type B, might be an effective alternative. STUDY DESIGN: Case series with planned data collection. SETTING: Otolaryngology department in a university hospital.
Botulinum toxin therapy in Frey's syndrome: a retrospective study of 440 treatments in 100 patients. Jansen S, Jerowski M, Ludwig L, Fischer-Krall E, Beutner D, Grosheva M. Clin Otolaryngol. 2017;42:295–300. doi: 10.1111/coa.12719.
Botulinum toxin injections have now been accepted as a safe and effective means of treating Frey's syndrome. As a result other treatment options such as topical and systemic anticholinergic drugs and several surgical options are now rarely used.
Objective: Botulinum toxin is a widely accepted, effective treatment for Frey's syndrome. While some patients need only one injection, others require repeated treatments. We aimed to describe the clinical features of patients with a more challenging treatment course.
We present a case of a woman operated 20 years ago of bilateral parotidectomy that developed Frey's syndrome (FS). We try to explain the causes of the delay request for therapy in FS. We got the disappearance of symptoms even after 20 years from surgery thanks to botulinum toxin injection.