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Fatal insomnia is an extremely rare neurodegenerative prion disease that results in trouble sleeping as its hallmark symptom. [2] The majority of cases are familial ( fatal familial insomnia [FFI]), stemming from a mutation in the PRNP gene, with the remainder of cases occurring sporadically ( sporadic fatal insomnia [sFI]).
Cases of objective total insomnia are extremely rare. The few that have been recorded have predominantly been ascribed to a rare incurable genetic disorder called fatal familial insomnia, which patients rarely survive for more than 26 months after the onset of illness—often much less. [19]
TSEs of humans include Creutzfeldt–Jakob disease, Gerstmann–Sträussler–Scheinker syndrome, fatal familial insomnia, and kuru, as well as the recently discovered variably protease-sensitive prionopathy and familial spongiform encephalopathy. Creutzfeldt-Jakob disease itself has four main forms, the sporadic (sCJD), the hereditary/familial ...
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Fatal familial insomnia, an extremely rare and universally-fatal prion disease that causes a complete cessation of sleep. Hypopnea syndrome, abnormally shallow breathing or slow respiratory rate while sleeping; Idiopathic hypersomnia, a primary, neurologic cause of long-sleeping, sharing many similarities with narcolepsy [83]
Onset insomnia is characterized by difficulty falling asleep at night, leaving people tossing and turning for hours. Maintenance insomnia involves the inability to stay asleep throughout the night ...
Insomnia is one of the most common sleep disorders, with the Centers for Disease Control and Prevention reporting that as many as one in two adults experience short-term bouts, while one in 10 may ...
A rare genetic condition can cause a prion-based, permanent and eventually fatal form of insomnia called fatal familial insomnia [66] Physical exercise: exercise-induced insomnia is common in athletes in the form of prolonged sleep onset latency [67] Increased exposure to the blue light from artificial sources, such as phones or computers [68]