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Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. Its measurement is commonly used to detect risk of atherosclerotic cardiovascular disease. Its measurement is commonly used to detect risk of atherosclerotic cardiovascular disease.
ApoB is an integral apoprotein whereas the others are peripheral apoproteins. Apolipoprotein synthesis such as ApoA4 in hypothalamus involves in the integration of signals for regulation of food intake [ 5 ] which is regulated by vagal nerve and cholecystokinin .
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 also known as C->U-editing enzyme APOBEC-1 is a protein that in humans is encoded by the APOBEC1 gene. [ 5 ] This gene encodes a member of the APOBEC protein family and the cytidine deaminase enzyme family.
Apolipoprotein B deficiency is an autosomal dominant disorder resulting from a missense mutation which reduces the affinity of apoB-100 for the low-density lipoprotein receptor (LDL Receptor). This causes impairments in LDL catabolism, resulting in increased levels of low-density lipoprotein in the blood.
These enzymes, when misregulated, are a major source of mutation in numerous cancer types. [5] [6] [8] When the expression of APOBEC family proteins is triggered, accidental mutations in somatic cells can lead to the development of oncogenes, cells which have the potential to develop into a tumor.
4018 n/a Ensembl ENSG00000198670 n/a UniProt P08519 n/a RefSeq (mRNA) NM_005577 n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 6: 160.53 – 160.66 Mb n/a PubMed search n/a Wikidata View/Edit Human Lipoprotein(a) is a low-density lipoprotein variant containing a protein called apolipoprotein(a). Genetic and epidemiological studies have identified lipoprotein(a) as a risk factor for ...
However, she later had a “horrible experience,” possibly due to “this gene, GDF15, which makes you extremely prone to nausea,” she said on Howard Stern’s SiriusXM show last month. “I ...
C->U-editing enzyme APOBEC-4, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4, is a protein that in humans is encoded by the APOBEC4 gene. It is primarily expressed in testis and found in mammals, chicken, but not fishes.