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Cocaine stimulates the mesolimbic pathway in the brain. [15] Mental effects may include an intense feeling of happiness, sexual arousal, loss of contact with reality, or agitation. [12] Physical effects may include a fast heart rate, sweating, and dilated pupils. [12] High doses can result in high blood pressure or high body temperature. [16]
Chemical structure of cocaine. The biosynthesis of cocaine has long attracted the attention of biochemists and organic chemists. This interest is partly motivated by the strong physiological effects of cocaine, but a further incentive was the unusual bicyclic structure of the molecule. The biosynthesis can be viewed as occurring in two phases ...
Trituration of the free base from cocaine hydrochloride (or "cooking") is done by dissolving the cocaine hydrochloride in water over constant heat, while simultaneously adding a base (such as baking soda) to form the free base cocaine. The free base of cocaine forms a solid "rock", pieces of which can be smoked directly (crack cocaine). [4]
It is a primary metabolite of cocaine, [1] and is pharmacologically inactive. [2] It is the corresponding carboxylic acid of cocaine, its methyl ester. It is formed in the liver by the metabolism of cocaine by hydrolysis, catalysed by carboxylesterases, and subsequently excreted in the urine. It is readily synthesised by boiling cocaine ...
The basic physical difference between E. coca and E. novogranatense is that the E. coca (sometimes called E. bolivianum) has larger leaves that are elliptical, oval and broader near the middle (broad-elliptic) and darker green color
How does pink cocaine affect someone? It can be hard to determine how the drug cocktail may affect someone after ingesting it. WebMD said this is due to several factors: the types of drugs mixed ...
A partial autopsy conducted on former One Direction singer Liam Payne found multiple substances in his system when he fell to his death from the third-floor balcony of a hotel room in Argentina ...
A formal lab test of the white substance found at the White House on Sunday has come back positive for cocaine, Secret Service spokesman Anthony Guglielmi said.