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The eutomer is the enantiomer having the desired pharmacological activity, [4] e.g., as an active ingredient in a drug. The distomer , on the other hand, is the enantiomer of the eutomer which may have undesired bioactivity or may be bio-inert.
An example of such an enantiomer is the sedative thalidomide, which was sold in a number of countries around the world from 1957 until 1961. It was withdrawn from the market when it was found to cause birth defects. One enantiomer caused the desirable sedative effects, while the other, unavoidably [23] present in equal quantities, caused birth ...
One enantiomer of a drug may have a desired beneficial effect while the other may cause serious and undesired side effects, or sometimes even beneficial but entirely different effects. [1] The desired enantiomer is known as an eutomer while the undesired enantiomer is known as the distomer. [ 2 ]
The (R)-enantiomer has the desired sedative effect while the (S)-enantiomer harbors embryo-toxic and teratogenic effects. Attempting to extract solely R-thalidomide does not remove the risk of birth defects, as it was demonstrated that the "safe" R-thalidomide undergoes an in vivo chiral inversion to the "teratogenic" S-thalidomide.
The observed rotation of the sample is the weighted sum of the optical rotation of each anomer weighted by the amount of that anomer present. Therefore, one can use a polarimeter to measure the rotation of a sample and then calculate the ratio of the two anomers present from the enantiomeric excess, as long as one knows the rotation of each pure anomer.
In chemistry, racemization is a conversion, by heat or by chemical reaction, of an optically active compound into a racemic (optically inactive) form. This creates a 1:1 molar ratio of enantiomers and is referred to as a racemic mixture (i.e. contain equal amount of (+) and (−) forms).
Curtis called the fires, "Life on life's terms," adding, "If ever there was need for the use of the phrase MY HAND IN YOURS, it is right now. Take care of each other. Stay out of the way and let ...
As the l-isomer of glucose, it is the enantiomer of the more common d-glucose. l -Glucose does not occur naturally in living organisms, but can be synthesized in the laboratory. l -Glucose is indistinguishable in taste from d -glucose, [ 1 ] but cannot be used by living organisms as a source of energy because it cannot be phosphorylated by ...