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An enteric coating is a polymer barrier applied to oral medication that prevents its dissolution or disintegration in the gastric environment. [1] This helps by either protecting drugs from the acidity of the stomach, the stomach from the detrimental effects of the drug, or to release the drug after the stomach (usually in the upper tract of the intestine). [2]
Triamcinolone may interact with medications which are CYP3A4 inhibitors. CYP3A4 inhibitor may decrease the break down of triamcinolone which increases its amount in patients' body to cause toxicity. [6] Examples of CYP3A4 inhibitors include clarithromycin, verapamil, ketoconazole and anti-viral drugs, including nirmatrelvir and ritonavir. [7]
Buccal tablets offer many advantages over other solid dosage forms also intended for oral administration (e.g. enteric-coated tablets, chewable tablets, and capsules). Buccal tablets can be considered in patients who experience difficulty in swallowing, since these tablets are absorbed into the blood stream between the gum and cheek.
Most oral PPI preparations are enteric-coated, due to the rapid degradation of the drugs in the acidic conditions of the stomach. For example omeprazole is unstable in acid with a half-life of 2 min at pH 1–3, but is significantly more stable at pH 7 (half-life ca. 20 h).
Anaprazole is a pharmaceutical drug used for the treatment of duodenal ulcers. It is classified as a proton pump inhibitor (PPI). [1] It was approved for use in China in 2023. [2] It is formulated as its sodium salt, anaprazole sodium, in enteric-coated tablets. [2]
Erythromycyclamine retains the antibacterial properties of erythromycin oral administration. The prodrug, dirithromycin, is provided as enteric coated tablets to protect it from acid catalyzed hydrolysis in the stomach. Orally administered dirithromycin is absorbed rapidly into the plasma, largely from the small intestine.
Methenamine mandelate is provided as an enteric coated tablet and is taken four times daily, whereas methenamine hippurate is available only in non-coated tablet form and is taken twice daily. [8] [14] [9] [4] Non-coated methenamine tablets can have a chemical taste described as sweet, sour, and/or metallic. [14] [37] [38]
Hence, erythromycin should not be administered to people using these drugs, or drugs that also prolong the QT interval. Other examples include terfenadine (Seldane, Seldane-D), [ 26 ] astemizole (Hismanal), [ 27 ] cisapride [ 28 ] (Propulsid, withdrawn in many countries for prolonging the QT time) and pimozide (Orap). [ 29 ]