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In animal cells, cell division with mitosis was discovered in frog, rabbit, and cat cornea cells in 1873 and described for the first time by the Polish histologist Wacław Mayzel in 1875. [18] [19] Bütschli, Schneider and Fol might have also claimed the discovery of the process presently known as "mitosis". [13]
Chromosomes at various stages of mitosis. Karyograms are generally made by chromosomes in prometaphase or metaphase. During these phases, the two copies of each chromosome (connected at the centromere) will look as one unless the image resolution is high enough to distinguish the two. Micrograph of human chromosomes before further processing.
The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
Cell division in prokaryotes (binary fission) and eukaryotes (mitosis and meiosis). The thick lines are chromosomes, and the thin blue lines are fibers pulling on the chromosomes and pushing the ends of the cell apart. The cell cycle in eukaryotes: I = Interphase, M = Mitosis, G 0 = Gap 0, G 1 = Gap 1, G 2 = Gap 2, S = Synthesis, G 3 = Gap 3.
Mitochondria are small structures in cells that generate energy for the cell to use, and are hence referred to as the "powerhouses" of the cell. Mitochondrial DNA (mtDNA) is not transmitted through nuclear DNA (nDNA). In humans, as in most multicellular organisms, mitochondrial DNA is inherited only from the mother's ovum.
Nuclear reproduction: mitosis – interphase – prophase – metaphase – anaphase – telophase; programmed cell death – apoptosis – cell senescence; Metabolism: enzyme - activation energy - proteolysis – cooperativity; Cellular respiration. Glycolysis – Pyruvate dehydrogenase complex – Citric acid cycle – electron transport ...
The cell was first discovered by Robert Hooke in 1665, which can be found to be described in his book Micrographia. In this book, he gave 60 observations in detail of various objects under a coarse, compound microscope. One observation was from very thin slices of bottle cork. Hooke discovered a multitude of tiny pores that he named "cells".
It is difficult to identify and group chromosomes based on simple staining because the uniform colour of the structures makes it difficult to differentiate between the different chromosomes. Therefore, techniques like G‑banding were developed that made "bands" appear on the chromosomes.