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Chlormadinone acetate (CMA), sold under the brand names Belara, Gynorelle, Lutéran, and Prostal among others, is a progestin and antiandrogen medication which is used in birth control pills to prevent pregnancy, as a component of menopausal hormone therapy, in the treatment of gynecological disorders, and in the treatment of androgen-dependent conditions like enlarged prostate and prostate ...
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an antiandrogen and progestin medication used in the treatment of androgen-dependent conditions such as acne, excessive body hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender individuals ...
17α-Hydroxyprogesterone derivatives . Chlormadinone acetate; Cyproterone acetate; Megestrol acetate; Osaterone acetate; 19-Norprogesterone derivatives . Nomegestrol acetate; 19-Nortestosterone derivatives
Cyproterone acetate, the most well-known and widely used steroidal antiandrogen. Steroid ring system. ... Chlormadinone acetate = 17α-acetoxy-6-chloro- ...
SAAs include cyproterone acetate (CPA), megestrol acetate, chlormadinone acetate, and spironolactone. [76] [77] These drugs are steroids, and similarly to NSAAs, act as competitive antagonists of the AR, reducing androgenic activity in the body.
Cyproterone, also known by its developmental code name SH-80881, is a steroidal antiandrogen which was studied in the 1960s and 1970s but was never introduced for medical use. [ 1 ] [ 2 ] [ 3 ] It is a precursor of cyproterone acetate (CPA), an antiandrogen, progestin , and antigonadotropin which was introduced instead of cyproterone and is ...
All contain an estrogen, ethinylestradiol or mestranol, [1] [2] in varying amounts, and one of a number of different progestogens. (Regarding the estrogen, the inactive 3-methyl ether of ethinylestradiol, which must be metabolized by the liver into the active ethinylestradiol; 50 μg of mestranol is equivalent to only 35 μg of ethinylestradiol and should not be used when high-dose [50 μg ...
A steroidal antiandrogen (SAA) is an antiandrogen with a steroidal chemical structure. [1] [2] [3] They are typically antagonists of the androgen receptor (AR) and act both by blocking the effects of androgens like testosterone and dihydrotestosterone (DHT) and by suppressing gonadal androgen production.
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