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Chlormadinone acetate (CMA), sold under the brand names Belara, Gynorelle, Lutéran, and Prostal among others, is a progestin and antiandrogen medication which is used in birth control pills to prevent pregnancy, as a component of menopausal hormone therapy, in the treatment of gynecological disorders, and in the treatment of androgen-dependent conditions like enlarged prostate and prostate ...
Chlormadinone acetate = 17α-acetoxy-6-chloro-δ 6-progesterone Clometerone (L-38000) = 6α-chloro-16α-methylprogesterone Cyproterone (SH-80881) = 1,2α-methylene-6-chloro-δ 6 -17α-hydroxyprogesterone
All contain an estrogen, ethinylestradiol or mestranol, [1] [2] in varying amounts, and one of a number of different progestogens. (Regarding the estrogen, the inactive 3-methyl ether of ethinylestradiol, which must be metabolized by the liver into the active ethinylestradiol; 50 μg of mestranol is equivalent to only 35 μg of ethinylestradiol and should not be used when high-dose [50 μg ...
Another large study reported a rate of impotence of only 9.3% with bicalutamide relative to 6.5% for standard care (the controls), a rate of decreased libido of only 3.6% with bicalutamide relative to 1.2% for standard care, and a rate of 9.2% with bicalutamide for hot flashes relative to 5.4% for standard care. [125]
Estradiol/megestrol acetate (Mego-E, Chinese Injectable No. 2) Estradiol benzoate/estradiol valerate/hydroxyprogesterone caproate (Sin-Ol) Estradiol benzoate butyrate/algestone acetophenide (Redimen, Soluna, Unijab)
[125] [126] [127] Combined birth control pills containing different progestins result in SHBG levels that are increased 1.5- to 2-fold with levonorgestrel, 2.5- to 4-fold with desogestrel and gestodene, 3.5- to 4-fold with drospirenone and dienogest, and 4- to 5-fold with cyproterone acetate. [125]
Cyproterone is a potent antiandrogen, similarly to CPA. [5] [6] However, it has approximately three-fold lower potency as an antagonist of the androgen receptor (AR) relative to CPA. [6] Like CPA, cyproterone is actually a weak partial agonist of the AR, and hence has the potential for both antiandrogenic and androgenic activity in some ...
Estradiol valerate and cyproterone acetate (brand name Femilar) – introduced in Finland (only) in 1993 [3] Estradiol valerate and dienogest (brand names Qlaira, Natazia) – introduced in Europe in 2009 and the U.S. Tooltip United States in 2010 [4] Estradiol and nomegestrol acetate (brand name Zoely) – introduced in Europe in 2011 [5]