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A polyproline helix is a type of protein secondary structure which occurs in proteins comprising repeating proline residues. [1] A left-handed polyproline II helix (PPII, poly-Pro II, κ-helix [2]) is formed when sequential residues all adopt (φ,ψ) backbone dihedral angles of roughly (-75°, 150°) and have trans isomers of their peptide bonds.
Multiple prolines and/or hydroxyprolines in a row can create a polyproline helix, the predominant secondary structure in collagen. The hydroxylation of proline by prolyl hydroxylase (or other additions of electron-withdrawing substituents such as fluorine ) increases the conformational stability of collagen significantly. [ 20 ]
In addition to the protein domains, there are unusual transmembrane elements formed by peptides. A typical example is gramicidin A, a peptide that forms a dimeric transmembrane β-helix. [8] This peptide is secreted by gram-positive bacteria as an antibiotic. A transmembrane polyproline-II helix has not been reported in natural proteins ...
Polyproline I helix; Protein–protein interaction; Medicine ... Perusahaan Perdagangan Indonesia, trading company; Philips Phonographische Industries, ...
In such rings the polypeptide has the conformation of beta sheet or of type II polyproline helix (PPII). A number of glutamines and asparagines help bind short peptides (with the PPII conformation) in the groove of class II MHC ( Major Histocompatibility Complex ) proteins [ 2 ] by forming these motifs.
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Resilin, however, has an absence of an alpha-helix leading to a randomly coiled structure and a disordered structure. [10] This is primarily due to the significantly high proline content in resilin. Proline is a bulky amino acid that has the ability to cause a kink the peptide chain and due to the sterically hindered side chains, it is not able ...
57479 233210 Ensembl ENSG00000126464 ENSMUSG00000046574 UniProt Q9ULL5 E9PYL2 RefSeq (mRNA) NM_020719 NM_175022 RefSeq (protein) NP_065770 NP_778187 Location (UCSC) Chr 19: 49.59 – 49.63 Mb Chr 7: 44.68 – 44.7 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Proline-rich 12 (PRR12) is a protein of unknown function encoded by the gene PRR12. Gene The Homo sapiens PRR12 gene is ...