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Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. [ 5 ] [ 6 ] [ 7 ] It achieves this by inhibiting Ca 2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors . [ 8 ]
Major adverse effects of dantrolene include general muscle weakness, sedation, and occasionally hepatitis. [5] Other common spasmolytic agents include: methocarbamol, carisoprodol, chlorzoxazone, cyclobenzaprine, gabapentin, metaxalone, and orphenadrine.
Dantrolene is a muscle relaxant that appears to work directly on the ryanodine receptor to prevent the release of calcium. After the widespread introduction of treatment with dantrolene, the mortality of malignant hyperthermia fell from 80% in the 1960s to less than 5%. [ 5 ]
Common side effects include general discomfort in the eye, redness, dryness, tearing, itching, burning, moderate temporary vision changes, and mild pain. In rare cases, you may experience more ...
When used in a vein, onset of action is generally within one minute and effects last for up to 10 minutes. [7] Common side effects include low blood pressure, increased saliva production, muscle pain, and rash. [7] Serious side effects include malignant hyperthermia, hyperkalemia and allergic reactions.
But because daily-use Cialis is prescribed at a lower dosage, some side effects appear less common and are generally less severe. For instance, in clinical trials, 11 to 15 percent of men reported ...
Neuroleptic malignant syndrome (NMS) is a rare [5] [6] but life-threatening reaction that can occur in response to antipsychotics (neuroleptic) or other drugs that block the effects of dopamine. [ 1 ] [ 7 ] Symptoms include high fever , confusion, rigid muscles, variable blood pressure, sweating, and fast heart rate. [ 1 ]
According to a scientific review, the root may have weak anti-androgen (i.e. anti-male sex hormone) effects. Otherwise, there's not a ton of research on the link between licorice root and ...
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