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Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic obesity in adults in combination with a reduced-calorie diet and increased physical activity. [4] [6] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone atypical antidepressant. [4]
In the US, the drug label contains warnings for increased heart rate, suicidal behavior and ideation, glaucoma, mood and sleep disorders, creatinine elevation, and metabolic acidosis. Some of these warnings are based on historical observations in epilepsy patients taking topiramate.
By comparison, other medications that are FDA-approved for weight loss, including Qsymia and Contrave, are combinations of much older drugs. These medications are typically associated with much ...
The company has a single product, Contrave, approved for use in the United States in 2014. [ 2 ] [ 3 ] Contrave was designed not only to curb hunger but also reduce cravings. [ 3 ] Observation of the market performance of Qsymia and Belviq suggest overall low demand for pharmaceutical obesity therapies, calling into question earnings potential ...
The biotech hasn't even resubmitted its application for Contrave. It could take six months after that to get approved. By that time, Qsymia and Belviq will be well into their launches; I doubt the ...
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[8] [14] Naltrexone, as naltrexone/bupropion (brand name Contrave), is also used to treat obesity. [15] It is on the World Health Organization's List of Essential Medicines. [16] In 2021, it was the 254th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [17] [18]
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