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For dementia and Alzheimer’s, researchers found a U-shaped association with total choline intake. This means that people at the first and fourth quartiles experienced higher odds of developing ...
L-α-Glycerophosphorylcholine (alpha-GPC, choline alfoscerate, sn-glycero-3-phosphocholine) is a natural choline compound found in the brain. It is also a parasympathomimetic acetylcholine precursor [ 1 ] which has been investigated for its potential for the treatment of Alzheimer's disease [ 2 ] and other dementias .
"Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta‑analysis". Experimental and Therapeutic Medicine. 17 (3): 1611– 1624. doi: 10.3892/etm.2018.7129. ISSN 1792-0981. PMC 6364145. PMID 30783428
Rivastigmine, sold under the brand name Exelon among others, is an acetylcholinesterase inhibitor used for the treatment of dementia associated with Alzheimer's disease and with Parkinson's disease. [ 4 ] [ 6 ] [ 7 ] Rivastigmine can be administered orally or via a transdermal patch ; the latter form reduces the prevalence of side effects, [ 8 ...
The findings align with earlier research showing that dietary choline supplements help astrocytes manage issues caused by the APOE4 gene, a major Alzheimer’s risk factor.
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Acetylcholine Acetylcholinesterase Acetylcholinesterase inhibition. Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, [1] inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, [2] thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ...
In general, the word "choline" describes the various quaternary ammonium salts containing the N,N,N-trimethylethanolammonium cation. Found in most animal tissues, choline is a primary component of the neurotransmitter acetylcholine and functions with inositol as a basic constituent of lecithin. Choline also prevents fat deposits in the liver ...