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For dementia and Alzheimer’s, researchers found a U-shaped association with total choline intake. This means that people at the first and fourth quartiles experienced higher odds of developing ...
Studies performed in the 1980s demonstrated significant impairment of cholinergic markers in Alzheimer's patients. [ 4 ] Thus it was proposed that degeneration of cholinergic neurons in the basal forebrain and the associated loss of cholinergic neurotransmission in the cerebral cortex and other areas contributed significantly to the ...
L-α-Glycerophosphorylcholine (alpha-GPC, choline alfoscerate, sn-glycero-3-phosphocholine) is a natural choline compound found in the brain. It is also a parasympathomimetic acetylcholine precursor [ 1 ] which has been investigated for its potential for the treatment of Alzheimer's disease [ 2 ] and other dementias .
The findings align with earlier research showing that dietary choline supplements help astrocytes manage issues caused by the APOE4 gene, a major Alzheimer’s risk factor.
Choline bitartrate – Choline bitartrate is a tartaric acid salt containing choline (41% choline by molecular weight). One meta-analysis found choline bitartrate to be ineffective at improving any measure of cognitive performance. [36] Citicoline – Compound consisting of choline and cytidine. A meta-analysis found that it may be effective ...
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In Alzheimer disease (AD), amyloid formation may decrease the ability of these receptors to transmit signals, leading to decreased cholinergic activity. As these receptors themselves appear relatively unchanged in the disease process, they have become a potential therapeutic target when trying to improve cognitive function in patients with AD.
Research indicates that Mediterranean and MIND diets may protect against Alzheimer’s, potentially due to lower intake of inflammatory saturated fats and sugars and higher consumption of vitamins ...
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