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Studies using mixed-sex chimeric chickens demonstrated that male (ZZ) and female (ZW) cells maintain their distinct sexual identity even when transplanted into tissues of the opposite sex. The DMRT1 gene, located on the Z chromosome, has been identified as a key regulator of CASI in birds.
Offspring have two sex chromosomes: an offspring with two X chromosomes (XX) will develop female characteristics, and an offspring with an X and a Y chromosome (XY) will develop male characteristics, except in various exceptions such as individuals with Swyer syndrome, that have XY chromosomes and a female phenotype, and de la Chapelle Syndrome ...
This represents the size of a composite genome based on data from multiple individuals but it is a good indication of the typical amount of DNA in a haploid set of chromosomes because the Y chromosome is quite small. [7] Most human cells are diploid so they contain twice as much DNA (~6.2 billion base pairs).
XX male syndrome, also known as de la Chapelle syndrome, is a rare intersex condition in which an individual with a 46,XX karyotype develops a male phenotype. [2] Synonyms for XX male syndrome include 46,XX testicular difference of sex development (or 46,XX DSD) [3] [4] [5] [6]
Sex chromosomes evolve from standard pairs of autosomal chromosomes. [28] In a large number of organisms, the sex-determination systems presently observed are products of sex chromosome turnover. Sex chromosome turnover is a process defined as when the type of the sex chromosome changes as a product of a change in the identity of the sex ...
In the absence of a Y chromosome, the fetus will undergo female development. This is because of the presence of the sex-determining region of the Y chromosome, also known as the SRY gene. [5] Thus, male mammals typically have an X and a Y chromosome (XY), while female mammals typically have two X chromosomes (XX).
Sperm sorting by flow cytometry is an established technique in veterinary practice, and in the dairy industry most female cows are artificially inseminated with sorted semen to increase the number of female calves (using sperm sorting is less common in other species of farm animals, however artificial insemination is common). [16]
The International System for Human Cytogenomic Nomenclature (ISCN; previously the International System for Human Cytogenetic Nomenclature) is an international standard for human chromosome nomenclature, which includes band names, symbols, and abbreviated terms used in the description of human chromosome and chromosome abnormalities.