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In the US, the states of Kansas, Georgia, Alabama, Tennessee, Missouri, Louisiana, Mississippi, Arkansas, and New York banned K2, herbal incense. JWH-018 was banned by controlled substances act on December 21, 2012. Law enforcement officials in Canada asked Huffman to serve as a consultant and expert witness.
JWH-018, JWH-073, CP 47,497 (and its homologues), and HU-210, as well as leonotis leonurus, have been all banned in Latvia since 2005. [128] After the first confirmed lethal case from the use of legal drugs in late 2013, parliament significantly increased the number of temporarily banned substances used in Spice and similar preparations.
JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
JWH-020: Naphthoylindole: 128 ± 17: 205 ± 20: CB 1 (1.6x) JWH-030: Naphthoylpyrrole: 87 ± 3: 320 ± 127: CB 1 (3.7x) JWH-031: Naphthoylpyrrole: 399 ± 109: JWH-032: Naphthoylpyrrole >10000 >10000 — JWH-033: Naphthoylpyrrole: 666 ± 77: JWH-036: Naphthoylpyrrole: 309 ± 11: JWH-042 [6] Naphthoylindole >10000: 5050 ± 192: CB 2: JWH-043 [6 ...
Marketed under the names spice, spike, flamingo, or K2 — this underground drug has become one of the most inexpensive and dangerous ways to get high, reports say. Videos surfacing online have ...
Chemical structure of JWH-018, a simple naphthoylindole. Naphthoylindoles are a class of synthetic cannabinoids. [1] ... typically marketed as "herbal incense blends ...
JWH-018, a potent synthetic cannabinoid agonist discovered by John W. Huffman at Clemson University. It was often sold in legal smoke blends collectively known as "spice". Several countries and states have moved to ban it legally. JWH-073; CP-55940, produced in 1974, this synthetic cannabinoid receptor agonist is many times more potent than THC.
JWH-073, a synthetic cannabinoid, is an analgesic chemical from the naphthoylindole family that acts as a full agonist [3] at both the CB 1 and CB 2 cannabinoid receptors. It is somewhat selective for the CB 1 subtype, with affinity at this subtype approximately 5× the affinity at CB 2 . [ 4 ]
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