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Most glia are derived from ectodermal tissue of the developing embryo, in particular the neural tube and crest. The exception is microglia , which are derived from hematopoietic stem cells . In the adult, microglia are largely a self-renewing population and are distinct from macrophages and monocytes, which infiltrate an injured and diseased CNS.
These can further differentiate into neurons or glial cells. Neuroepithelial cells are a class of stem cell and have the ability to self-renew. During the formation of the neural tube, neuroepithelial cells undergo symmetric proliferative divisions that give rise to two new neuroepithelial cells.
The ventral part of the neural tube contains the basal plate, which is primarily associated with motor (i.e., muscle) control. The spinal cord develops from the posterior neural tube. As the spinal cord develops, the cells making up the wall of the neural tube proliferate and differentiate into the neurons and glia of the spinal cord.
[5] [6] The neural plate is the source of the majority of neurons and glial cells of the CNS. The neural groove forms along the long axis of the neural plate, and the neural plate folds to give rise to the neural tube. [7] This process is known as neurulation. [8] When the tube is closed at both ends it is filled with embryonic cerebrospinal ...
The neural plate is the source of the majority of neurons and glial cells of the CNS. A groove forms along the long axis of the neural plate and, by week four of development, the neural plate wraps in on itself to give rise to the neural tube, which is filled with cerebrospinal fluid (CSF). [1]
The floor plate is a structure integral to the developing nervous system of vertebrate organisms. Located on the ventral midline of the embryonic neural tube, the floor plate is a specialized glial structure that spans the anteroposterior axis from the midbrain to the tail regions.
Radial glial cells, or radial glial progenitor cells (RGPs), are bipolar-shaped progenitor cells that are responsible for producing all of the neurons in the cerebral cortex. RGPs also produce certain lineages of glia , including astrocytes and oligodendrocytes .
This is a flowchart of the development of Schwann cells from neural crest cells. Neural crest cells are found in the dorsal neural tube from which nerves and glia alike grow [1] and Neural crest cells are the precursors to many various tissue types including enteric neurons and glia.