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Phentermine and topiramate was developed by Vivus, a California pharmaceutical company. In December 2009, Vivus, Inc. submitted a new drug application (NDA) to the FDA and on 1 March 2010, Vivus, Inc. announced that the FDA accepted the NDA for review.
If you take Qsymia, the starting dose is 3.75mg of phentermine and 23mg of topiramate daily for 14 days. The dose then increases to 7.5mg of phentermine and 46mg of topiramate daily for 90 days.
Topiramate, sold under the brand name Topamax among others, is a medication used to treat epilepsy and prevent migraines. [9] It has also been used for alcohol dependence and essential tremor. [9] For epilepsy, this includes treatment for generalized or focal seizures. [10] It is taken orally (by mouth). [9]
A doctor will probably get you started on a 0.25 milligram (mg) dose that will slowly increase to 2.4mg. ... at 3.75mg of phentermine and 23mg of topiramate and increase after two weeks to 7.5mg ...
[6] [6] Peak concentrations of phentermine are reached 6 hours following oral administration of a dose of 15 mg. [6] The steady-state levels of phentermine with continuous administration have been found to be around 200 ng/mL in clinical studies. [6] The oral bioavailability of phentermine is not affected by intake of a high-fat meal. [6]
6. Phentermine-topiramate. Dr. Teixeira explains that phentermine and topiramate are two extended release capsules that work together to help with weight loss by decreasing appetite ...
Phentermine is a substituted amphetamine and topiramate has an unknown mechanism of action Approved for weight management (short-term) by the FDA but not the European Medicines Agency [ 54 ] 10% [ 55 ] or 8.25 kilograms (18.2 lb) [ 56 ]
Topamax – an anticonvulsant used to treat epilepsy and migraine headaches; Trileptal (oxcarbazepine) – an anticonvulsant used as a mood stabilizer; Trintellix (vortioxetine) – an antidepressant of the serotonin modulator and stimulator class; Tegretol (carbamazepine) – an anticonvulsant used as a mood stabilizer
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