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An accidental release of phosgene gas at a DuPont facility in West Virginia killed one employee in 2010. [41] The US Chemical Safety Board released a video detailing the accident. [42] Six years later, a phosgene leak occurred in a BASF plant in South Korea, where a contractor inhaled a lethal dose of phosgene. [43]
In the pharmaceutical industry, drug dissolution testing is routinely used to provide critical in vitro drug release information for both quality control purposes, i.e., to assess batch-to-batch consistency of solid oral dosage forms such as tablets, and drug development, i.e., to predict in vivo drug release profiles. [1]
There are a number of methods by which tablets and capsules can be modified in order to allow for sustained release of the active compound as it moves through the digestive tract. One of the most common methods is to embed the active ingredient in an insoluble porous matrix, such that the dissolving drug must make its way out of the matrix ...
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]
The drug is expelled via the laser-drilled hole visible on the left side of the tablet. The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it.
The daily Svenska Dagbladet newspaper said authorities had found traces of phosgene. The gas has a strong odor that can cause vomiting and breathing trouble and was used as a weapon in World War I.
The tablet press is an essential piece of machinery for any pharmaceutical and nutraceutical manufacturer. Tablet presses must allow the operator to adjust the position of the lower and upper punches accurately, so that the tablet weight, thickness and density/hardness can each be controlled.
A growing property insurance crisis may make it hard to get a mortgage in parts of the country in the coming decades, Federal Reserve Chairman Jerome Powell said Tuesday in testimony before Congress.