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Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus. [7] [11] The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, [10] making smallpox the only human disease to have been eradicated to date.
The history of smallpox extends into pre-history. [1] Genetic evidence suggests that the smallpox virus emerged 3,000 to 4,000 years ago. [2] Prior to that, similar ancestral viruses circulated, but possibly only in other mammals, and possibly with different symptoms.
The most common type of smallpox, ordinary, historically has devastated populations with a 30% death rate. The smallpox virus is transmittable through bodily fluids and materials contaminated with infected materials. Generally, face-to-face contact is required for an individual to contract smallpox as a result of an interaction with another human.
The symptoms of smallpox are rash on the skin and blisters filled with raised liquid. [ citation needed ] The disease killed an estimated 400,000 Europeans annually during the 19th century and one-third of all the blindness of that time was caused by smallpox. 20 to 60% of all the people that were infected died and 80% of all the children with ...
One Native tribe majorly affected by the smallpox epidemic was the Mandan tribe. The Mandans traditionally lived along the Missouri River. They had an extraordinarily rich culture, due to them hosting many European and American travelers. The Mandan villages consisted of 12 to 100 lodges and were well organized with a hierarchy of leaders.
They were sold at the extremely high price of five guineas, and Haygarth set out to show that the high cost was unnecessary. He did this by comparing the results from dummy wooden tractors with a set of allegedly "active" metal tractors, and published his findings in a book On the Imagination as a Cause & as a Cure of Disorders of the Body .
Symptoms begin 12 to 48 hours after exposure to the virus and last for about 1 to 3 days. Even after recovering, infected individuals can be contagious for two more weeks.
No treatment is available, and the only protection is vaccination. The virus is usually transmitted by prolonged face-to-face contact with a person showing symptoms. The incubation period averages 12–14 days. [18] One of the most feared diseases of human history, smallpox was still causing an estimated 2 million deaths every year as late as 1967.