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Throughout her tenure at the University of Rochester, Gorbunova's research team continued to focus on the naked mole rat as a key to understanding cancer resistance among animals. In 2013, Gorbunova and Seluanov identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat. [9]
The Golan Heights blind mole-rat (Spalax golani) and the Judean Mountains blind mole-rat (Spalax judaei) are also resistant to cancer, but by a different mechanism. [ 35 ] In July 2023 a study reported the transference of the gene responsible for HMW-HA from a naked mole rat to mice leading to improved health and an approximate 4.4 percent ...
Cells of naked mole rats, a species in which cancer has never observed, show hypersensitivity to contact inhibition. [8] This finding may provide a clue to cancer resistance. Furthermore, recent studies have further revealed some mechanisms of contact inhibition of proliferation and its potential implications in cancer therapy.
It may look like a whiskered cocktail sausage, but the naked mole rat's incredible biology may one day improve countless lives. Meet the naked mole-rat: impervious to pain and cancer, and lives ...
Rochelle Buffenstein is an American comparative biologist currently working as Research Professor at the University of Illinois Chicago.Previously, she was a senior principal investigator at Calico Life Sciences, an Alphabet, Inc. funded research and development company investigating the biology that controls aging and lifespan where she used the extraordinarily long-lived cancer resistant ...
Tumour-suppressing genes have been identified in 65 species of mammal. Naked mole rats experience low cancer rates even though they are smaller than humans. Crocodiles and birds also experience low cancer rates. Birds may have inherited their resistance from their much larger dinosaur ancestors. [2]
Additionally, almost no incidence of cancer has ever been detected in naked mole rats. Nearly all of the differences found between these two organisms, which are otherwise rather genetically similar, was in somatic maintenance. Naked mole rats were found to have higher levels of superoxide dismutase, a reactive oxygen species clearing antioxidant.
For example, Eilian's cancerous mole was much darker than the other moles on her body, she notes. Melanomas are more common in “very fair-skinned people,” who have red or blond hair, or blue ...