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Adapalene, sold under the brand name Differin among others, is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. [6] Studies have found adapalene is as effective as other retinoids, while causing less irritation. [7]
Differin gel is an NBC Select staff favorite and Wellness Award winner for best acne treatment — it contains 0.1% adapalene, which is an over-the-counter retinoid often used to treat acne ...
Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves. [6]The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; [7] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
It contains clindamycin, as the phosphate, a lincosamide antibacterial; adapalene, a synthetic retinoid; and benzoyl peroxide, an oxidizing agent. [2] It is applied to the skin . [ 2 ]
Benzoyl peroxide is a common acne-fighting ingredient found in a variety of skin care products. Shop cleansers, treatments and more from brands like Cerave and La Roche Posay.
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Dimethicone (a skin-smoothing silicone) and hyaluronic acid (a humectant that pulls water into your skin for hydration), two lightweight ingredients recommended by Dr. Rabach for helping to make ...
In human skin, topical retinoids increase collagen production, induce epidermal hyperplasia, and decrease keratinocyte and melanocyte atypia. Topical tretinoin is the most extensively investigated retinoid therapy for photoaging. [23] Topical tretinoin can be used for mild to severe photoaging in people of all skin types.
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