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Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside . [1] [2] The term can also refer more generally to any organic molecule that contains amino sugar substructures.
More than 60 amino sugars are known, with one of the most abundant being N-acetyl-D-glucosamine (a 2-amino-2-deoxysugar), which is the main component of chitin. Derivatives of amine containing sugars, such as N -acetylglucosamine and sialic acid , whose nitrogens are part of more complex functional groups rather than formally being amines, are ...
In enzymology, an aminoglycoside N6'-acetyltransferase (EC 2.3.1.82) is an enzyme that catalyzes the chemical reaction. acetyl-CoA + kanamycin-B CoA + N 6 '-acetylkanamycin-B. Thus, the two substrates of this enzyme are acetyl-CoA and kanamycin B, whereas its two products are CoA and N6'-acetylkanamycin-B.
Aminocyclitols are found as a component of aminoglycoside antibiotics which is also called as pseudosugars or pseudosaccharides. Aminocyclitols have chemical structures of a carbon ring with amine functional group(s). The class of aminocyclitol containing natural products can be divided by ring sizes or types of precursors.
G418 (geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1.It is produced by Micromonospora rhodorangea. [1] G418 blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. [1]
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Aminoglycoside-3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the addition of phosphate from ATP to the 3'-hydroxyl group of a 4,6-disubstituted aminoglycoside, such as kanamycin. [2]
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