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It is reported to have an elimination half-life of 2.8 hours, [3] although a review of 14 studies found that the mean terminal half-life ranged between 2 and 11 hours, and one study even reported a terminal half-life of 33 hours. [5] Buspirone is metabolized primarily by CYP3A4, and prominent drug interactions with inhibitors and inducers of ...
Buspirone is indicated for GAD, ... Both fluoxetine and its active metabolite have a long half life therefore it causes the least withdrawal symptoms. [16] [22]
A common metabolite of several azapirones including buspirone, gepirone, ipsapirone, revospirone, and tandospirone is 1-(2-pyrimidinyl)piperazine (1-PP). [ 47 ] [ 48 ] [ 49 ] 1-PP possesses 5-HT 1A partial agonist and α 2 -adrenergic antagonist actions and likely contributes overall mostly to side effects.
Cerebrovascular accident (stroke); Myocardial infarction (heart attack); Cardiomyopathy; Congestive heart failure; Bradycardia; Dysphoria; Hallucinations; Feelings of ...
Buspirone is sometimes used off-label to reduce sexual dysfunction associated with the use of SSRIs. [ 54 ] [ 55 ] [ 56 ] A number of non-SSRI drugs are not associated with sexual side effects (such as bupropion , mirtazapine , tianeptine , agomelatine , tranylcypromine , and moclobemide [ 57 ] [ 58 ] [ 59 ] ).
The final class of barbiturates are known as long-acting barbiturates (the most notable one being phenobarbital, which has a half-life of roughly 92 hours). This class of barbiturates is used almost exclusively as anticonvulsants, although on rare occasions they are prescribed for daytime sedation. Barbiturates in this class are not used for ...
Elimination half-life: Tandospirone: 2–3 hours 1-PP ... It is a member of the azapirone class of drugs and is closely related to other azapirones like buspirone and ...
Long half-life benzodiazepines like diazepam [1] or chlordiazepoxide are preferred to minimize rebound effects and are available in low dose forms. Some people may not fully stabilize between dose reductions, even when the rate of reduction is slowed.
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