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In the synergistic response, the applied antibiotics work together to produce an effect more potent than if each antibiotic were applied singly. [1] Compare to the additive effect , where the potency of an antibiotic combination is roughly equal to the combined potencies of each antibiotic singly, and antagonistic effect, where the potency of ...
Synergistic effect is similar to additive effect, having a combination effect greater than additive effect. It can produce an effect of 2+2 > 4 when two drugs are used together. Additive effect can also be found in a majority of combination therapies , although synergistic effect is more common.
A combination drug or a fixed-dose combination (FDC) is a medicine that includes two or more active ingredients combined in a single dosage form. [1] Terms like "combination drug" or "combination drug product" can be common shorthand for an FDC product (since most combination drug products are currently FDCs), although the latter is more precise if in fact referring to a mass-produced product ...
Let and be doses of compounds 1 and 2 producing in combination an effect . We denote by D e 1 {\displaystyle D_{e1}} and D e 2 {\displaystyle D_{e2}} the doses of compounds 1 and 2 required to produce effect e {\displaystyle e} alone (assuming this conditions uniquely define them, i.e. that the individual dose-response functions are bijective).
A combination antibiotic is one in which two ingredients are added together for additional therapeutic effect. [1] One or both ingredients may be antibiotics. [1]
Both medications have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight. [7] In September 2014, a sustained release formulation of the drug was approved for marketing in the United States under the brand name Contrave.
[71] [72] Fosfomycin has the highest number of synergistic combinations among antibiotics and is almost always used as a partner drug. [73] Methicillin-resistant Staphylococcus aureus infections may be treated with a combination therapy of fusidic acid and rifampicin. [71]
Combined drug intoxication use often carries with it more risk than use of a single drug, due to an increase in side effects, and drug synergy. The potentiating effect of one drug on another is sometimes considerable and here the licit drugs and medicines – such as alcohol , nicotine and antidepressants – have to be considered in ...