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Amyloidosis (am-uh-loi-DO-sis) is a rare disease that occurs when a protein called amyloid builds up in organs. This amyloid buildup can make the organs not work properly. Organs that may be affected include the heart, kidneys, liver, spleen, nervous system and digestive tract.
Amyloidosis (am-uh-loi-DO-sis) is a rare disease that occurs when a substance called amyloid builds up in your organs. Amyloid is an abnormal protein that is produced in your bone marrow and can be deposited in any tissue or organ.
There's no cure for amyloidosis. But treatment can help manage signs and symptoms and limit further production of amyloid protein. If the amyloidosis has been triggered by another condition, such as rheumatoid arthritis or tuberculosis, treating the underlying condition can be helpful. Medications. Chemotherapy.
So in summary, amyloid is a disease of abnormal proteins that deposit in your organs and cause dysfunction. The heart is very commonly involved. It becomes very stiff from amyloid deposition, but the treatment is to treat the underlying problem.
While there is no cure for amyloidosis, several treatment options are available to help manage symptoms and limit production of amyloid protein. Your doctors will work with you to choose the best treatment for the type of amyloidosis you have.
Dr. Martha Grogan, a Mayo Clinic cardiologist and director of the Cardiac Amyloid Clinic at Mayo Clinic in Rochester, Minnesota, explains what cardiac amyloidosis is, why knowing the type of amyloid is key to treatment, and what's on the horizon to help patients with this rare condition.
Advanced diagnosis and treatment. Amyloidosis is a rare disease that can be difficult to diagnose. Mayo Clinic specialists use the latest technology, such as mass spectrometry and specialized imaging, to pinpoint the type of amyloidosis you have.
JACKSONVILLE, Fla. — Mayo Clinic researchers led a laboratory study that found a new way to prevent the accumulation of amyloid plaque – a key feature of Alzheimer’s disease – by eliminating a class of molecules called heparan sulfates that form on brain cells.
So first of all, what is amyloid? How does it affect your heart? I'll explain the tests that you need to evaluate your heart--basically, what do all those numbers mean? And what are your treatment options if you have cardiac amyloidosis? Well, amyloid is a disease of what we call protein misfolding.
Early diagnosis of cardiac amyloidosis is crucial for successful treatment in addition to identifying which kind of amyloid you have. Tests and procedures to determine this may include blood or urine tests, an electrocardiogram (ECG or EKG), echocardiogram, biopsy tissue sample or MRI of the heart.