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Pain experienced by individuals depends on the severity of the polyneuropathy. It may be dull and constant in some individuals while being sharp and lancinating in others. [4] In many subjects, tenderness is seen upon the palpitation of muscles in the feet and legs. [1]
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
Ankle, feet, and leg swelling This occurs because of a phenomenon known as third spacing. Third spacing occurs because the heart is unable to pump the blood throughout the body, and thus the fluid pools up in your veins. The fluid then eventually leaves your veins and enters the interstitial space, causing swelling.
Other symptoms can develop based on the cause. For example, if portal vein thrombosis develops due to liver cirrhosis, bleeding or other signs of liver disease may be present. If portal vein thrombosis develops due to pylephlebitis, signs of infection such as fever, chills, or night sweats may be present. [citation needed]
Liver. Acute hemorrhage into a hepatocellular carcinoma causes severe upper right quadrant pain, and may be life-threatening, requiring emergency surgery or other emergency intervention. [5] A tumor can expand the size of the liver several times and consequent stretching of its capsule can cause aching pain in the right hypochondrium.
The rates of nonalcoholic fatty liver disease — which can lead to life-threatening conditions, including cirrhosis and cancer of the organ — have been soaring over the past three decades, a ...
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