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A Cochrane review, though, found that metformin was only slightly effective for decreasing androgen levels in women with PCOS. [125] Metformin also has significant effects on the gut microbiome, such as its effect on increasing agmatine production by gut bacteria, but the relative importance of this mechanism compared to other mechanisms is ...
But metformin isn’t without its side effects. Though the side effects can be a bummer, a key strategy for mitigating them is timing. In other words, taking metformin at the right time of day can ...
Metformin shows may also help reduce the severity of diseases relating to insulin and glucose levels. This includes PCOS, certain tumor-related cancers, gestational diabetes and age-related diseases.
Type 1 diabetes is a disease caused by the lack of insulin. Thus, insulin is the main treatment agent for type 1 and is typically administered via subcutaneous injection. Type 2 diabetes is a disease of insulin resistance by cells. Type 2 diabetes is the most common type of diabetes.
a health care professional who is qualified by the American Association of Diabetes Educators to teach people with diabetes how to manage their condition. In the US, the health care team for diabetes should ideally include a diabetes educator, preferably a C.D.E. Charcot foot
The high-level blood glucose for a long time will lead to dysfunction of a variety of tissues. [1] Type 2 diabetes is a progressive condition in which the body becomes resistant to the normal effects of insulin and/or gradually loses the capacity to produce enough insulin in the pancreas. [2]
[1] [2] It is regarded as a second-line option compared to metformin, due to metformin's well-established safety and efficacy. [1] Use of glimepiride is recommended in conjunction with lifestyle modifications such as diet and exercise. [1] It is taken by mouth, [1] reaching a peak effect within three hours and lasting for about a day. [1]
Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...
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