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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
A traditional method to evaluate druglikeness is to check compliance of Lipinski's rule of five, which covers the numbers of hydrophilic groups, molecular weight and hydrophobicity. Since the drug is transported in aqueous media like blood and intracellular fluid, it has to be sufficiently water-soluble in the absolute sense (i.e. must have a ...
Christopher A. Lipinski is a medicinal chemist who is working at Pfizer, Inc. [1] He is known for his "rule of five" , an algorithm that predicts drug compounds that are likely to have oral activity. [ 1 ]
The Supercomputing Facility for Bioinformatics and Computational Biology, (SCFBio), IIT Delhi, was established in July 2002 with funding from Department of Biotechnology under the guidance of Prof. B. Jayaram. It aims at developing novel scientific methods and new software for genome analysis, protein structure prediction, and in silico drug ...
TV Guide gave the film two out of four stars and stated: "The original Excessive Force was a ridiculous vehicle for low-level action star Thomas Ian Griffith; that film's only virtue was its colorful supporting cast. This film (originally written as a stand-alone project) is easier to take seriously, but lacks much in the way of colorful ...
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Lipinski won the gold medal at the 1998 Nagano Games at the age of 15, the youngest winner of an Olympic winter event. Weir competed at the 2006 and 2010 Winter Olympics.
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