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Acoltremon also known as WS-12 is an investigational new drug which is being evaluated for the treatment of dry eye syndrome. [ 1 ] Acoltremon that acts as a potent and selective activator ( opener ) of the TRPM8 calcium channel, which is responsible for the sensation of coldness produced by menthol .
Given the difficulty in treating scleroderma, treatments with a smaller evidence base are often tried to control the disease. These include antithymocyte globulin and mycophenolate mofetil ; some reports have shown improvements in the skin symptoms, as well as delaying the progress of systemic disease, but neither has been subjected to large ...
Diabetes, for example, is the leading cause of new cases of blindness in those aged 20–74, with ocular manifestations such as diabetic retinopathy and macular edema affecting up to 80% of those who have had the disease for 15 years or more.
Scleroderma is also associated with an increased risk of cardiovascular disease. [ 46 ] According to a study of an Australian cohort, between 1985 and 2015, the average life expectancy of a person with scleroderma increased from 66 years to 74 years (the average Australian life expectancy increased from 76 to 82 years in the same period).
“As with all research, finding a greater sample of people affected by these conditions using GLP-1 medications may help to identify risk factors for these types of problems,” Ali added.
According to the study, 75 percent of flavored e-cigarettes and their refill liquids were found to contain Diacetyl, "a flavoring chemical linked to cases of severe respiratory disease" such as ...
A 2014 review concluded that e-cigarette aerosol contains far fewer carcinogens than tobacco smoke, and concluded that e-cigarettes "impart a lower potential disease burden" than traditional cigarettes. [61] However, e-cigarette vapor has components not present in traditional cigarettes, which potentially offset some of these benefits.
The agency's inscrutable approach to harm-reducing nicotine products sacrifices consumer choice and public health on the altar of youth protection.