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Acoltremon also known as WS-12 is an investigational new drug which is being evaluated for the treatment of dry eye syndrome. [ 1 ] Acoltremon that acts as a potent and selective activator ( opener ) of the TRPM8 calcium channel, which is responsible for the sensation of coldness produced by menthol .
Menthol may also enhance the activity of glycine receptors and negatively modulate 5-HT 3 receptors and nAChRs. [11] Menthol is widely used in dental care as a topical antibacterial agent, effective against several types of streptococci and lactobacilli. [12] Menthol also lowers blood pressure and antagonizes vasoconstriction through TRPM8 ...
Given the difficulty in treating scleroderma, treatments with a smaller evidence base are often tried to control the disease. These include antithymocyte globulin and mycophenolate mofetil ; some reports have shown improvements in the skin symptoms, as well as delaying the progress of systemic disease, but neither has been subjected to large ...
According to the study, 75 percent of flavored e-cigarettes and their refill liquids were found to contain Diacetyl, "a flavoring chemical linked to cases of severe respiratory disease" such as ...
Four menthol vaping products were authorized by the US Food and Drug Administration on Friday, the first non-tobacco-flavored e-cigarette products to get the agency’s sign-off.
A 2014 review concluded that e-cigarette aerosol contains far fewer carcinogens than tobacco smoke, and concluded that e-cigarettes "impart a lower potential disease burden" than traditional cigarettes. [61] However, e-cigarette vapor has components not present in traditional cigarettes, which potentially offset some of these benefits.
The decision lends new credibility to vaping companies’ longstanding argument that their products can help blunt the toll of smoking, which is blamed for 480,000 U.S. deaths annually due to ...
Diabetes, for example, is the leading cause of new cases of blindness in those aged 20–74, with ocular manifestations such as diabetic retinopathy and macular edema affecting up to 80% of those who have had the disease for 15 years or more.