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Megasphaera is a genus of Bacillota bacteria classified within the class Negativicutes. [1] [2] This classification has been reexamined. [3]
Bacillota (synonym Firmicutes) is a phylum of bacteria, most of which have gram-positive cell wall structure. [2] The renaming of phyla such as Firmicutes in 2021 remains controversial among microbiologists, many of whom continue to use the earlier names of long standing in the literature.
They range from spherical forms, such as Megasphaera and Veillonella, to curved rods, as typified by the selenomonads. Selenomonas has a characteristic crescent shape, with flagella inserted on the concave side, while Sporomusa is similar, but nonmotile. Their names refer to this distinctive morphology: selene means moon, and musa means banana. [5]
[1] The branching order proposed by Carl Woese was based on molecular phylogeny, which was considered revolutionary as all preceding models were based on discussions of morphology. (v. Monera). [2] Several models have been proposed since and no consensus is reached at present as to the branching order of the major bacterial lineages. [3]
They range from spherical forms, such as Megasphaera and Veillonella, to curved rods, as typified by the Selenomonads. [2] Selenomonas has a characteristic crescent-shape, with flagella inserted on the concave side, while Sporomusa is similar but non-motile. Their names refer to this distinctive morphology: selene means moon, and musa means banana.
Although some lactate is normally produced in the rumen, it is normally metabolized by such organisms as Megasphaera elsdenii and, to a lesser extent, Selenomonas ruminantium and some other organisms. With high grain consumption, the concentration of dissociated organic acids can become quite high, resulting in rumen pH dropping below 6.
Graphic depicting the human skin microbiota, with relative prevalences of various classes of bacteria. The human microbiome is the aggregate of all microbiota that reside on or within human tissues and biofluids along with the corresponding anatomical sites in which they reside, [1] [2] including the gastrointestinal tract, skin, mammary glands, seminal fluid, uterus, ovarian follicles, lung ...
[22] [2] Treatment with TopI inhibitors stabilizes the intermediate cleavable complex, preventing DNA re-ligation, and inducing lethal DNA strand breaks. [ 22 ] [ 23 ] Camptothecin -derived TopI inhibitors function by forming a ternary complex with TopI-DNA and are able to stack between the base pairs that flank the cleavage site due to their ...