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ADHD can be difficult to tell apart from other conditions. [16] [22] It represents the extreme lower end of the continuous dimensional trait (bell curve) of executive functioning and self-regulation, which is supported by twin, brain imaging and molecular genetic studies. [39] The precise causes of ADHD are unknown in most individual cases.
Large, high quality research has found small differences in the brain between ADHD and non-ADHD patients. [1] [15] Jonathan Leo and David Cohen, critics who reject the characterization of ADHD as a disorder, contended in 2003 and 2004 that the controls for stimulant medication usage were inadequate in some lobar volumetric studies, which makes it impossible to determine whether ADHD itself or ...
A genetic variant associated with ADHD has been found at higher frequency in more nomadic populations and those with more of a history of migration. [10] Consistent with this, the health status of nomadic Ariaal men was higher if they had the ADHD associated genetic variant (7R alleles), whereas in recently sedentary (non-nomadic) Ariaal ...
NF-1 is a complex multi-system human disorder caused by the mutation of a gene on chromosome 17 that is responsible for production of a protein, called neurofibromin 1, which is needed for normal function in many human cell types. NF-1 causes tumors along the nervous system which can grow anywhere on the body. NF-1 is one of the most common ...
A few of the common ones are attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), intellectual disabilities, motor disorders, and communication disorders among others. Some causes can contribute to these disorders like genetic factors (genetics, family medical history), [51] environmental factors (excessive stress ...
A 2017 study [8] [9] tested all 20,000 genes in about 4,300 families with children with rare developmental difficulties in the UK and Ireland in order to identify if these difficulties had a genetic cause. They found 14 new developmental disorders caused by spontaneous genetic mutations not found in either parent (such as a fault in the CDK13 ...
The estimate suggests that the condition is slightly less common than Rett syndrome, a genetic disorder that causes babies to rapidly lose coordination, speech and mobility and affects about 1 in ...
ADHD also has high rates of comorbidity with these disorders in adulthood, further leading clinicians to pursue evaluation for these disorders over ADHD. [10] Furthermore, the stigma surrounding ADHD causes many adults to forego seeking treatment altogether. [13] Another barrier to diagnosis is faced by highly intelligent or high-functioning ...
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