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Chlortalidone is considered a first-line medication for treatment of high blood pressure. [2] Some recommend chlortalidone over hydrochlorothiazide. [1] [15] A meta-analysis of randomized controlled trials found that chlortalidone is more effective than hydrochlorothiazide for lowering blood pressure, while the two drugs have similar toxicity.
Estrogen dosages for prostate cancer Route/form Estrogen Dosage Oral: Estradiol: 1–2 mg 3x/day Conjugated estrogens: 1.25–2.5 mg 3x/day Ethinylestradiol: 0.15–3 mg/day Ethinylestradiol sulfonate: 1–2 mg 1x/week Diethylstilbestrol: 1–3 mg/day Dienestrol: 5 mg/day Hexestrol: 5 mg/day Fosfestrol: 100–480 mg 1–3x/day Chlorotrianisene ...
Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland. [1] Symptoms may include frequent urination, trouble starting to urinate, weak stream, inability to urinate, or loss of bladder control. [1]
Custirsen, with aliases including custirsen sodium, OGX-011, and CC-8490, is an investigational drug that is under clinical testing for the treatment of cancer. It is an antisense oligonucleotide (ASO) targeting clusterin expression. [1] In metastatic prostate cancer, custirsen showed no benefit in improving overall survival. [2] [3]
Prostate cancer is a major topic of ongoing research. From 2016–2020, over $1.26 billion was invested in prostate cancer research, representing around 5% of global cancer research funds. [122] This places prostate cancer 10th among 18 common cancer types in funding per cancer death, and 9th in funding per disability-adjusted life year lost. [123]
Androgen deprivation therapy (ADT), also called androgen ablation therapy or androgen suppression therapy, is an antihormone therapy whose main use is in treating prostate cancer. Prostate cancer cells usually require androgen hormones, such as testosterone, to grow. ADT reduces the levels of androgen hormones, with drugs or surgery, to prevent ...
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