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Hemagglutination, or haemagglutination, is a specific form of agglutination that involves red blood cells (RBCs). It has two common uses in the laboratory: blood typing and the quantification of virus dilutions in a haemagglutination assay .
A schematic diagram of the experimental setup to detect hemagglutination for blood typing. Hemagglutination blood typing detection: [24] This method consists of measuring the blood’s reflectance spectrum alone (non-agglutination), and that of blood mixed with antibody reagents (agglutination) using a waveguide-mode sensor. As a result, some ...
The hemagglutination assay or haemagglutination assay (HA) and the hemagglutination inhibition assay (HI or HAI) were developed in 1941–42 by American virologist George Hirst as methods for quantifying the relative concentration of viruses, bacteria, or antibodies.
Hemagglutination is the process by which red blood cells agglutinate, meaning clump or clog. The agglutin involved in hemagglutination is called hemagglutinin . In cross-matching , donor red blood cells and the recipient's serum or plasma are incubated together.
A similar specific treponemal test for syphilis is the Treponema pallidum hemagglutination assay or TPHA. TPHA is an indirect hemagglutination assay used for the detection and titration of antibodies against the causative agent of syphilis , Treponema pallidum subspecies pallidum .
Hemagglutinin (HA) in influenza A virus (IAV) has at least 18 different subtypes. [7] These subtypes are named H1 through H18. H16 was discovered in 2004 on IAVs isolated from black-headed gulls from Sweden and Norway.
Red cell agglutination in a patient with cold agglutinin disease. In hematology, red cell agglutination or autoagglutination is a phenomenon in which red blood cells clump together, forming aggregates.
Cold hemagglutination was first reported by Landsteiner in 1903 [30] [26] and found to occur in human beings in 1918. [31] [26] The association of cold hemagglutination with hemolysis was described in 1937 by Rosenthal and Corten. [32] [26] During the 1960s, Dacie [33] [26] and Schubothe [34] published systematic descriptions of 16 CAD patients ...