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Insulin aspart, sold under the brand name NovoLog, among others, is a modified type of medical insulin used to treat type 1 and type 2 diabetes. [17] It is generally used by injection under the skin but may also be used by injection into a vein . [ 17 ]
In January 2018, Reuters reported that Novo had offered to acquire Ablynx for $3.1 billion - having made an unreported offer in mid-December for the company. [25] However, the Ablynx board rejected this offer the same day, explaining that the price undervalued the business. [25] Ultimately Novo lost out to Sanofi who bid $4.8 billion. Later, in ...
Humulin was the first medication produced using modern genetic engineering techniques in which actual human DNA is inserted into a host cell (E. coli in this case). The host cells are then allowed to grow and reproduce normally, and due to the inserted human DNA, they produce a synthetic version of human insulin.
It works the same as human insulin by increasing the amount of glucose that tissues take in and decreasing the amount of glucose made by the liver. [5] Insulin lispro was first approved for use in the United States in 1996. [5] [8] [9] It is a manufactured analogue of human insulin where two amino acids have swapped positions. [10]
Non-human insulins have caused allergic reactions in some patients related to the extent of purification, formation of non-neutralising antibodies is rarely observed with recombinant human insulin (insulin human rDNA) but allergy may occur in some patients. This may be enhanced by the preservatives used in insulin preparations, or occur as a ...
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In 1832 produced chloral hydrate, the first synthetic sleeping drug. In 1833 French chemist Anselme Payen was the first to discover an enzyme , diastase . In 1834, François Mothes and Joseph Dublanc created a method to produce a single-piece gelatin capsule that was sealed with a drop of gelatin solution.
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