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4,7-Dichloroquinoline was first reported in a patent filed by IG Farben in 1937. [2] However, its synthesis was not investigated in detail until chloroquine was developed as an antimalarial drug. [ 3 ] : 130–132 A route to the intermediate starting from 3-chloroaniline was developed by chemists at Winthrop Chemical Co .
[1] [4] Chloroquine is a member of the drug class 4-aminoquinoline. [1] As an antimalarial, it works against the asexual form of the malaria parasite in the stage of its life cycle within the red blood cell. [1] How it works in rheumatoid arthritis and lupus erythematosus is unclear. [1] Chloroquine was discovered in 1934 by Hans Andersag.
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Deutsch: Synthese von Chloroquin aus 4,7-Dichlorchinolin und 1-Diethylamino-4-aminopentan English: Synthesis of chloroquine from 4,7-dichloroquinoline and 1-Diethylamino-4-aminopentane Date
Elton John's gift may be his song, but that doesn't mean he loves them all.. During an appearance on The Late Show with Stephen Colbert on Tuesday, Dec. 17, the 77-year-old musician spoke about ...
[3] [4] Although all risk cannot be excluded, it remains a treatment for rheumatic disease during pregnancy. [5] Hydroxychloroquine is in the antimalarial and 4-aminoquinoline families of medication. [3] Hydroxychloroquine was approved for medical use in the United States in 1955. [3] It is on the World Health Organization's List of Essential ...