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Diagnosing Vitamin B12 Deficiency and Cancer [38] If cancer is suspected as the cause of vitamin B12 deficiency, several diagnostic steps are necessary: Blood Tests : A simple blood test can measure vitamin B12 levels, along with other markers such as homocysteine and methylmalonic acid, which may also indicate a deficiency.
If the symptoms are serious, frequent injections are typically recommended initially. [7] There are not enough studies that pills are effective in improving or eliminating symptoms. [12] Often, treatment may be needed for life. [13] Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14]
Both low-dose (2 mg/day) and high-dose CPA combined with an estrogen have been associated with vitamin B12 deficiency in women in some small studies. [268] [269] [7] Vitamin B12 deficiency in turn has been associated with depression, anxiety, irritability, and fatigue due to depletion of central monoamine neurotransmitters.
Cyanocobalamin is a form of vitamin B 12 used to treat and prevent vitamin B 12 deficiency except in the presence of cyanide toxicity. [7] [8] [2] The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer.
They may include diarrhea, feeling sick, hot flushes, itchiness, low blood potassium, allergic reactions, and high blood pressure. [2] Normal doses are considered safe in pregnancy. [5] No overdosage or toxicity has been reported with this drug. [2] Hydroxocobalamin is the natural form of vitamin B 12 and a member of the cobalamin family of ...
There are also two general causes of cytopenia: autoimmune and refractory. Autoimmune cytopenia is caused by an autoimmune disease when your body produces antibodies to destroy the healthy blood cells. Refractory cytopenia is caused by bone marrow not producing healthy blood cells, and can be a result of cancer.
Biological competition for vitamin B12 by diverticulosis, fistula, intestinal anastomosis, or infection by the marine parasite Diphyllobothrium latum (fish tapeworm) Selective vitamin B12 malabsorption (congenital—juvenile megaloblastic anemia 1—and drug-induced) Chronic pancreatitis; Ileal resection and bypass
Rarely, drugs (antibiotics, blood pressure medication, heart medication) can cause pancytopenia. For example, the antibiotic chloramphenicol can cause pancytopenia in some individuals. [1] Rarely, pancytopenia may have other causes, such as mononucleosis or other viral diseases. Increasingly, HIV is itself a cause of pancytopenia. [2]