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The hepatocyte is a cell in the body that manufactures serum albumin, fibrinogen, and the prothrombin group of clotting factors (except for Factors 3 and 4). It is the main site for the synthesis of lipoproteins, ceruloplasmin, transferrin, complement, and glycoproteins.
The hepatocytes are the main functional cells of the liver. They are large and polygonal epithelial cells that constitute roughly up to 80% of the liver mass.
Hepatocytes, the major parenchymal cells in the liver, play pivotal roles in metabolism, detoxification, and protein synthesis. Hepatocytes also activate innate immunity against invading...
Schulze et al. present an overview of the diverse functions of hepatocytes, including filtering blood, the secretion of bile, and lipid uptake and release.
Hepatocytes are the main epithelial cells of the liver parenchyma. They make up around 80% of the liver volume and 60% of the liver cell population (Standring, 2016). They are polygonal in shape and have six sides but may have as many as 12 sides per cell.
Hepatocytes, the major parenchymal cells in the liver, play pivotal roles in metabolism, detoxification, and protein synthesis. Hepatocytes also activate innate immunity against invading microorganisms by secreting innate immunity proteins.
Our analysis identified previously unknown subtypes of endothelial cells, Kupffer cells, and hepatocytes, with transcriptome-wide zonation of some of these populations.
The liver is a metabolically complex organ. Hepatocytes (liver parenchymal cells) perform the liver’s metabolic functions: Formation and excretion of bile as a component of bilirubin metabolism (see Overview of bilirubin metabolism) Regulation of carbohydrate homeostasis.
These large and polyhedral (six surfaces) cells make up 80% of the total cells of the liver. They can contain between two and four nuclei, which are large and spherical, occupying the centre of the cells. Each nucleus has at least two nucleoli. The typical lifespan of a hepatocyte is five months.
Hepatocytes form a crucially important cell layer that separates sinusoidal blood from the canalicular bile. They have a uniquely organized polarity with a basal membrane facing liver sinusoidal endothelial cells, while one or more apical poles can ...