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Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells.. A cytotoxic T cell (also known as T C, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8 + T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected by intracellular pathogens such as viruses or bacteria, or ...
The interaction of the extracellular IgV-like domains of CD8 with the α 3 portion of the Class I MHC molecule increases affinity for the T cell receptor of the cytotoxic T cell and the target cell such that they bound closely together during antigen-specific activation. In addition, CD8 co-receptor also plays a role in T cell signaling.
The activation of cross presenting dendritic cells is dependent on stimulation by CD4+ T helper cells. The co-stimulatory molecule CD40/CD40L along with the danger presence of an exogenous antigen are catalysts for dendritic cell licensing, and thus the cross presentation and activation of naive CD8+ cytotoxic T cells. [11]
The CD8 protein is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system.The CD8, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen-presenting cell (APC) in the context of class I MHC molecules.
Optimal CD8 + T cell response relies on CD4 + signalling. [44] CD4 + cells are useful in the initial antigenic activation of naive CD8 T cells, and sustaining memory CD8 + T cells in the aftermath of an acute infection. Therefore, activation of CD4 + T cells can be beneficial to the action of CD8 + T cells. [45] [46] [47]
They are generally CD8 +, which makes them MHC class I restricted. CTLs are able to eliminate most cells in the body since most nucleated cells express class I MHC molecules. The CTL-mediated immune system can be divided into two phases. In the first phase, functional effector CTLs are generated from naive T c cells through activation and ...
Apart from infections, bystander activation also plays an important role in antitumor immunity. [30] In human cancerous tissues, a high number of virus-specific, not tumor-specific, CD8+ T cells was detected. [30] This type of activation is considered to be beneficial for the host in terms of cancer clearance efficiency. [26]
All T cells derive from progenitor cells in the bone marrow, which become committed to their lineage in the thymus.All T cells begin as CD4-CD8-TCR- cells at the DN (double-negative) stage, where an individual cell will rearrange its T cell receptor genes to form a unique, functional molecule, which they, in turn, test against cells in the thymic cortex for a minimal level of interaction with ...
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