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  2. Complement fixation test - Wikipedia

    en.wikipedia.org/wiki/Complement_fixation_test

    The complement system is a system of serum proteins that react with antigen-antibody complexes. If this reaction occurs on a cell surface, it will result in the formation of trans-membrane pores and therefore destruction of the cell. The basic steps of a complement fixation test are as follows: [1] Serum is separated from the patient.

  3. Complement system - Wikipedia

    en.wikipedia.org/wiki/Complement_system

    Excessive complement activity contributes to severe Covid-19 symptoms and disease. [53] Although complement is intended to protect the body systems, under stress there can be more damage than protection. Research has suggested that the complement system is manipulated during HIV/AIDS, in a way that further damages the body. [54]

  4. Wassermann test - Wikipedia

    en.wikipedia.org/wiki/Wassermann_test

    The Wassermann test or Wassermann reaction (WR) [1] is an antibody test for syphilis, named after the bacteriologist August Paul von Wassermann, based on complement fixation. It was the first blood test for syphilis and the first in the nontreponemal test (NTT) category. Newer NTTs, such as the RPR and VDRL tests, have mostly replaced it.

  5. Anaphylatoxin - Wikipedia

    en.wikipedia.org/wiki/Anaphylatoxin

    Anaphylatoxins, or complement peptides, are fragments (C3a, C4a and C5a) that are produced as part of the activation of the complement system. [2] Complement components C3, C4 and C5 are large glycoproteins that have important functions in the immune response and host defense. [ 3 ]

  6. Classical complement pathway - Wikipedia

    en.wikipedia.org/wiki/Classical_complement_pathway

    Complement is responsible for immune inflammatory response in adipose tissues which has been implicated in the development of obesity. [8] Obesity in turn results in an abnormally high level of complement activation via production of the C1 component of the classical pathway, which can lead to tissue inflammation and eventually insulin ...

  7. Alternative complement pathway - Wikipedia

    en.wikipedia.org/wiki/Alternative_complement_pathway

    The alternative pathway is a type of cascade reaction of the complement system and is a component of the innate immune system, a natural defense against infections. The alternative pathway is one of three complement pathways that opsonize and kill pathogens. The pathway is triggered when the C3b protein directly binds a microbe. It can also be ...

  8. Total complement activity - Wikipedia

    en.wikipedia.org/wiki/Total_complement_activity

    One can interpret the CH50 value along with the individual's complement factor values to help determine the etiology. For example, if and individual has normal C3/C4 values but a decreased CH50, that can indicate a terminal complement pathway deficiency while if one has low C3 and CH50 values that can indicate an autoimmune condition such as ...

  9. C3b - Wikipedia

    en.wikipedia.org/wiki/C3b

    An example RCA is membrane cofactor protein (MCP; CD46), which is ubiquitously expressed and plays a critical role in protecting host cells from damage by the C3b. [1] Furthermore, host cells express p33 (globular C1q receptor) on the surface, which binds C1q, and prevents it from initiating complement activation.