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  2. Complement fixation test - Wikipedia

    en.wikipedia.org/wiki/Complement_fixation_test

    The complement system is a system of serum proteins that react with antigen-antibody complexes. If this reaction occurs on a cell surface, it will result in the formation of trans-membrane pores and therefore destruction of the cell. The basic steps of a complement fixation test are as follows: [1] Serum is separated from the patient.

  3. Complement system - Wikipedia

    en.wikipedia.org/wiki/Complement_system

    The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. [1]

  4. C3b - Wikipedia

    en.wikipedia.org/wiki/C3b

    An example RCA is membrane cofactor protein (MCP; CD46), which is ubiquitously expressed and plays a critical role in protecting host cells from damage by the C3b. [1] Furthermore, host cells express p33 (globular C1q receptor) on the surface, which binds C1q, and prevents it from initiating complement activation.

  5. Classical complement pathway - Wikipedia

    en.wikipedia.org/wiki/Classical_complement_pathway

    Complement is responsible for immune inflammatory response in adipose tissues which has been implicated in the development of obesity. [8] Obesity in turn results in an abnormally high level of complement activation via production of the C1 component of the classical pathway, which can lead to tissue inflammation and eventually insulin ...

  6. Wassermann test - Wikipedia

    en.wikipedia.org/wiki/Wassermann_test

    The Wassermann test or Wassermann reaction (WR) [1] is an antibody test for syphilis, named after the bacteriologist August Paul von Wassermann, based on complement fixation. It was the first blood test for syphilis and the first in the nontreponemal test (NTT) category. Newer NTTs, such as the RPR and VDRL tests, have mostly replaced it.

  7. Alternative complement pathway - Wikipedia

    en.wikipedia.org/wiki/Alternative_complement_pathway

    The alternative pathway is a type of cascade reaction of the complement system and is a component of the innate immune system, a natural defense against infections. The alternative pathway is one of three complement pathways that opsonize and kill pathogens. The pathway is triggered when the C3b protein directly binds a microbe. It can also be ...

  8. Lectin pathway - Wikipedia

    en.wikipedia.org/wiki/Lectin_pathway

    Structure of mannose in its α-D mannopyranose form. Mannan is a polymer of mannose.. The lectin pathway or MBL pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, [1] in that, after activation, it proceeds through the action of C4 and C2 to produce activated complement proteins further down the cascade.

  9. C1 complex - Wikipedia

    en.wikipedia.org/wiki/C1_complex

    Activation of the C1 complex initiates the classical complement pathway. This occurs when C1q binds to antigen-antibody complexes. The antibodies IgM or certain subclasses of IgG complexed with antigens are able to initiate the complement system: a single pentameric IgM can initiate the pathway, while several monomeric IgG molecules are needed. [3]