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In dermatopathology, the Tzanck test, also Tzanck smear, is scraping of an ulcer base to look for Tzanck cells. It is sometimes also called the chickenpox skin test and the herpes skin test. It is a simple, low-cost, and rapid office based test. [1] Tzanck cells (acantholytic cells) are found in: Herpes simplex [2] Varicella and herpes zoster
Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, [1] seen in diseases such as pemphigus vulgaris. [2]
Dermatology Grover's disease ( GD ) is a polymorphic, pruritic , papulovesicular dermatosis characterized histologically by acantholysis [ 2 ] : 529 with or without dyskeratosis. [ 3 ] Once confirmed, most cases of Grover's disease last six to twelve months, which is why it was originally called "transient".
Epidermolytic acanthoma manifests clinically as tiny, fleshy or white papules that range in size from 1 to 2 mm. They may exist alone or in groups. [2] [3] They often affect the trunk, extremities, or scrotum and vulva. [4]
Dermatology: Lethal acantholytic epidermolysis bullosa is a fatal genetic skin disorder caused by mutations in DSP [1] [2] [3]
Acantholytic dyskeratotic epidermal nevus is a cutaneous condition identical to the generalized form of Darier's disease. [ 1 ] : 849 "Acantholytic dyskeratotic epidermal nevus" is probably the same disorder.
Acanthocyte-like cells may be found in hypothyroidism, after splenectomy, and in myelodysplasia. [12] Acanthocytes should be distinguished from echinocytes, which are also called 'burr cells', which although crenated are dissimilar in that they have multiple, small, projecting spiculations at regular intervals on the cell membrane.
Elaine V. Fuchs is an American cell biologist known for her work on the biology and molecular mechanisms of mammalian skin and skin diseases, who helped lead the modernization of dermatology. Fuchs pioneered reverse genetics approaches, which assess protein function first and then assess its role in development and disease.